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. 1996 Jan;106(1):24-7.
doi: 10.1111/1523-1747.ep12326976.

Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus

T Bailin  1 , S T Lee, R A Spritz
Affiliations
Free article

Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus

T Bailin et al. J Invest Dermatol. 1996 Jan.
Free article

Abstract

We have determined the DNA sequence and genomic organization of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus. D12S53E encodes a melanosomal matrix protein whose expression is closely correlated with cellular melanin content and which is a frequent melanoma tumor antigen recognized by cytotoxic T lymphocytes. D12S53E is a likely candidate gene for some cases of human oculocutaneous albinism not associated with known albinism loci.

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