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. 1995 Dec;39(12):2606-9.
doi: 10.1128/AAC.39.12.2606.

Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy

D M Gakunju  1 , E K Mberu, S F Dossaji, A I Gray, R D Waigh, P G Waterman, W M Watkins
Affiliations

Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy

D M Gakunju et al. Antimicrob Agents Chemother. 1995 Dec.

Abstract

Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.

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