Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Feb;30(2):280-4.
doi: 10.1007/BF00215809.

Mitochondrial bioenergetics as affected by cationic detergents

M Bragadin  1 , P Dell'Antone
Affiliations

Mitochondrial bioenergetics as affected by cationic detergents

M Bragadin et al. Arch Environ Contam Toxicol. 1996 Feb.

Abstract

This paper examines the accumulation and toxicity mechanism of a cationic detergent, cetyltrimethylammonium (bromide) (CTAB), in energized rat liver mitochondria. The results suggest that: (1) the CTAB ion is accumulated in the mitochondrial matrix by a membrane potential-driven uptake mechanism; (2) accumulation may lead to a toxic effect, since it gives rise to collapse of the mitochondrial membrane potential (delta phi) which is correlated with ATP synthesis and which regulates Ca++ uptake; (3) collapse of delta phi may be due to enhanced permeability of the mitochondrial membrane to the ions (detergent effect); and (4) delta phi collapse and Ca++ and K+ release were also observed in another cationic detergent, NTAB, but not in the presence of anionic detergents.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Am Pharm Assoc Am Pharm Assoc. 1951 Jun;40(8):263-7 - PubMed
    1. Biochim Biophys Acta. 1970 Aug 4;216(1):13-21 - PubMed
    1. Arch Environ Contam Toxicol. 1994 Oct;27(3):410-4 - PubMed
    1. Proc Soc Exp Biol Med. 1974 May;146(1):85-91 - PubMed
    1. Biochim Biophys Acta. 1980 Sep 18;601(2):349-57 - PubMed

Publication types