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. 1996 Feb;30(2):280-4.
doi: 10.1007/BF00215809.

Mitochondrial bioenergetics as affected by cationic detergents

M Bragadin  1 , P Dell'Antone
Affiliations

Mitochondrial bioenergetics as affected by cationic detergents

M Bragadin et al. Arch Environ Contam Toxicol. 1996 Feb.

Abstract

This paper examines the accumulation and toxicity mechanism of a cationic detergent, cetyltrimethylammonium (bromide) (CTAB), in energized rat liver mitochondria. The results suggest that: (1) the CTAB ion is accumulated in the mitochondrial matrix by a membrane potential-driven uptake mechanism; (2) accumulation may lead to a toxic effect, since it gives rise to collapse of the mitochondrial membrane potential (delta phi) which is correlated with ATP synthesis and which regulates Ca++ uptake; (3) collapse of delta phi may be due to enhanced permeability of the mitochondrial membrane to the ions (detergent effect); and (4) delta phi collapse and Ca++ and K+ release were also observed in another cationic detergent, NTAB, but not in the presence of anionic detergents.

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