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Clinical Trial
. 1979 Mar 31;1(8118):690-2.
doi: 10.1016/s0140-6736(79)91146-2.

Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist

N R Peden, J H Saunders, K G Wormsley
Clinical Trial

Inhibition of pentagastrin-stimulated and nocturnal gastric secretion by ranitidine. A new H2-receptor antagonist

N R Peden et al. Lancet. .

Abstract

Ranitidine hydrochloride (an H2-receptor-blocking drug which does not contain the imidazole nucleus of histamine) powerfully inhibited nocturnal and pentagastrin-stimulated gastric secretion in fifteen patients with duodenal ulceration. The drug is satisfactorily absorbed and therefore warrants clinical trial.

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