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. 1996 Mar 2;312(7030):537-9.
doi: 10.1136/bmj.312.7030.537.

Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study

M Lehtinen  1 , J Dillner, P Knekt, T Luostarinen, A Aromaa, R Kirnbauer, P Koskela, J Paavonen, R Peto, J T Schiller, M Hakama
Affiliations

Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study

M Lehtinen et al. BMJ. .

Abstract

Objective: To study human papillomavirus type 16 in the aetiology of cervical carcinoma.

Design: Within a cohort of 18814 Finnish women followed up to 23 years a nested case-control study was conducted based on serological diagnosis of past infection with human papillomavirus type 16.

Subjects: 72 women (27 with invasive carcinoma and 45 with in situ carcinoma) and 143 matched controls were identified during the follow up.

Main outcome measure: Relative risk of cervical carcinoma in presence of IgG antibodies to human papillomavirus type 16.

Results: After adjustment for smoking and for antibodies to various other agents of sexually transmitted disease, such as herpes simplex virus type 2 and Chlamydia trachomatis, the only significant association was with infection with human papillomavirus type 16 (odds ratio 12.5; 95% confidence interval 2.7 to 57, 2P<0.001).

Conclusion: This prospective study provides epidemiological evidence that infection with human papillomavirus type 16 confers an excess risk for subsequent development of cervical carcinoma.

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Comment in

  • Human papillomavirus infection.
    Hines JF, Ghim SJ, Jenson AB. Hines JF, et al. BMJ. 1996 Mar 2;312(7030):522-3. doi: 10.1136/bmj.312.7030.522. BMJ. 1996. PMID: 8595268 Free PMC article. No abstract available.

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