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. 1996 Mar 22;271(5256):1723-6.
doi: 10.1126/science.271.5256.1723.

Neonatal tolerance revisited: turning on newborn T cells with dendritic cells

J P Ridge  1 , E J Fuchs, P Matzinger
Affiliations

Neonatal tolerance revisited: turning on newborn T cells with dendritic cells

J P Ridge et al. Science. .

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

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Comment in

  • Teetering on the brink of danger.
    Pennisi E. Pennisi E. Science. 1996 Mar 22;271(5256):1665-7. doi: 10.1126/science.271.5256.1665. Science. 1996. PMID: 8596923 No abstract available.
  • Immunological tolerance.
    Silverstein AM. Silverstein AM. Science. 1996 Jun 7;272(5267):1405-8. doi: 10.1126/science.272.5267.1405a. Science. 1996. PMID: 8633222 No abstract available.
  • Immunological tolerance.
    Blumberg N, Heal JM. Blumberg N, et al. Science. 1996 Jun 7;272(5267):1408. Science. 1996. PMID: 8633223 No abstract available.
  • Fetal immune response.
    Sarfati M, Delespesse G. Sarfati M, et al. Science. 1996 Aug 9;273(5276):722-3. Science. 1996. PMID: 8701318 No abstract available.
  • Keratinocytes and the danger model.
    Nickoloff BJ, Turka LA. Nickoloff BJ, et al. Science. 1996 Sep 13;273(5281):1479-80. Science. 1996. PMID: 8801631 No abstract available.

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