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. 1996 Mar 22;271(5256):1726-8.
doi: 10.1126/science.271.5256.1726.

Induction of protective CTL responses in newborn mice by a murine retrovirus

M Sarzotti  1 , D S Robbins, P M Hoffman
Affiliations

Induction of protective CTL responses in newborn mice by a murine retrovirus

M Sarzotti et al. Science. .

Abstract

The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

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Comment in

  • Teetering on the brink of danger.
    Pennisi E. Pennisi E. Science. 1996 Mar 22;271(5256):1665-7. doi: 10.1126/science.271.5256.1665. Science. 1996. PMID: 8596923 No abstract available.
  • Immunological tolerance.
    Silverstein AM. Silverstein AM. Science. 1996 Jun 7;272(5267):1405-8. doi: 10.1126/science.272.5267.1405a. Science. 1996. PMID: 8633222 No abstract available.
  • Immunological tolerance.
    Blumberg N, Heal JM. Blumberg N, et al. Science. 1996 Jun 7;272(5267):1408. Science. 1996. PMID: 8633223 No abstract available.
  • Fetal immune response.
    Sarfati M, Delespesse G. Sarfati M, et al. Science. 1996 Aug 9;273(5276):722-3. Science. 1996. PMID: 8701318 No abstract available.

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