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. 1996 Mar 22;271(5256):1728-30.
doi: 10.1126/science.271.5256.1728.

Induction of TH1 and TH2 immunity in neonatal mice

T Forsthuber  1 , H C Yip, P V Lehmann
Affiliations

Induction of TH1 and TH2 immunity in neonatal mice

T Forsthuber et al. Science. .

Abstract

The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (TH2) immune response. Thus, neonatal "tolerization" induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate TH2 or TH1 responses, depending on the mode of immunization.

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Comment in

  • Teetering on the brink of danger.
    Pennisi E. Pennisi E. Science. 1996 Mar 22;271(5256):1665-7. doi: 10.1126/science.271.5256.1665. Science. 1996. PMID: 8596923 No abstract available.
  • Immunological tolerance.
    Silverstein AM. Silverstein AM. Science. 1996 Jun 7;272(5267):1405-8. doi: 10.1126/science.272.5267.1405a. Science. 1996. PMID: 8633222 No abstract available.
  • Immunological tolerance.
    Blumberg N, Heal JM. Blumberg N, et al. Science. 1996 Jun 7;272(5267):1408. Science. 1996. PMID: 8633223 No abstract available.
  • Fetal immune response.
    Sarfati M, Delespesse G. Sarfati M, et al. Science. 1996 Aug 9;273(5276):722-3. Science. 1996. PMID: 8701318 No abstract available.

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