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. 1996 Feb 24;312(7029):471-2.
doi: 10.1136/bmj.312.7029.471.

Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992

L Bujan  1 , A Mansat, F Pontonnier, R Mieusset
Affiliations

Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992

L Bujan et al. BMJ. .

Abstract

Objectives: To investigate whether sperm production has changed during the past 16 years in the Toulouse area of France.

Design: Time series analysis of sperm donors' specimens between 1977 and 1992.

Setting: Sperm bank of university hospital in Toulouse, France.

Subjects: 302 healthy fertile men candidate sperm donors more than 20 and up to 45 years old and without any infertile brothers.

Main outcome measure: Spermatozoa concentration.

Results: Donors' mean age at time of donation was 34.05 (SD 5.13), but this increased significantly (P<0.001) during the study, from 32.4 in 1977 to 36 in 1992. Mean sperm count of samples was 83.12x10(6)/ml (SD 68.42x10(6)/ml). Sperm concentration was positively linked to the year of donation (Pearson's coefficient r=0.12, P<0.05), but this correlaton disappeared after adjustment for age of donors (r=0.09,P>0.05).

Conclusion: Sperm concentration has not changed with time in the Toulouse area.

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