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. 1996 Apr 5;272(5258):101-4.
doi: 10.1126/science.272.5258.101.

Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein

J M Ball  1 , P Tian, C Q Zeng, A P Morris, M K Estes
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Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein

J M Ball et al. Science. .

Abstract

The rotavirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope as subviral particles bud into the endoplasmic reticulum. NSP4 also causes an increase in intracellular calcium in insect cells. Purified NSP4 or a peptide corresponding to NSP4 residues 114 to 135 induced diarrhea in young (6 to 10 days old) CD1 mice. This disease response was age-dependent, dose-dependent, and specific. Electrophysiologic data from intestinal mucosa showed that the NSP4 114-135 peptide potentiates chloride secretion by a calcium-dependent signaling pathway. Diarrhea is induced when NSP4, acting as a viral enterotoxin, triggers a signal transduction pathway.

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  • New lessons for rotavirus vaccines.
    Glass RI, Gentsch JR, Ivanoff B. Glass RI, et al. Science. 1996 Apr 5;272(5258):46-8. doi: 10.1126/science.272.5258.46. Science. 1996. PMID: 8600533 Review. No abstract available.

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