doi: 10.1016/s0140-6736(79)91318-7.
Treatment of Paget's disease with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.)
- PMID: 86042
- DOI: 10.1016/s0140-6736(79)91318-7
Item in Clipboard
Treatment of Paget's disease with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.)
Lancet.
.
Abstract
18 patients with Paget's disease were treated orally with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.). In most cases bone resorption became normal within a week of treatment, whereas the return to normal bone formation took 3-6 months; this difference produced a transient imbalance between resorption and formation. In biopsy specimens taken during treatment the numbers of osteoclasts and osteoblasts decreased towards normal and excess osteoid disappeared.
Similar articles
-
Effects of disodium dichloromethylene diphosphonate on Paget's disease of bone.Lancet. 1979 Sep 8;2(8141):489-92. doi: 10.1016/s0140-6736(79)91551-4. Lancet. 1979. PMID: 90215 Clinical Trial.
-
Human calcitonin in the treatment of Paget's bone disease.Lancet. 1971 Jun 5;1(7710):1139-43. doi: 10.1016/s0140-6736(71)91657-6. Lancet. 1971. PMID: 4102856 No abstract available.
-
[Treatment of Paget's disease with salmon calcitonin].Rev Rhum Mal Osteoartic. 1977 Jan;44(1):59-66. Rev Rhum Mal Osteoartic. 1977. PMID: 319520 Clinical Trial. French. No abstract available.
-
Treatment of Paget's disease of bone (osteitis deformans) with sodium etidronate (EHDP).Clin Orthop Relat Res. 1977;(127):94-105. Clin Orthop Relat Res. 1977. PMID: 410576 Review. No abstract available.
-
Treatment of Paget's disease with a diphosphonate (sodium etidronate).Semin Drug Treat. 1972 Summer;2(1):77-81. Semin Drug Treat. 1972. PMID: 4558759 Review. No abstract available.
Cited by
-
Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease.Drugs. 1991 Feb;41(2):289-318. doi: 10.2165/00003495-199141020-00009. Drugs. 1991. PMID: 1709854 Review.
-
Immobilization-related hypercalcaemia--a possible novel mechanism and response to pamidronate.Postgrad Med J. 1990 Nov;66(781):918-22. doi: 10.1136/pgmj.66.781.918. Postgrad Med J. 1990. PMID: 2267202 Free PMC article.
-
Alendronate blocks metalloproteinase secretion and bone collagen I release by PC-3 ML cells in SCID mice.Clin Exp Metastasis. 1998 Nov;16(8):693-702. doi: 10.1023/a:1006524610591. Clin Exp Metastasis. 1998. PMID: 10211982
-
Treatment of osteoporosis: current and future.Ann Rheum Dis. 1991 Oct;50(10):663-5. doi: 10.1136/ard.50.10.663. Ann Rheum Dis. 1991. PMID: 1958084 Free PMC article. Review. No abstract available.
-
Clinical experience with the use of two diphosphonates in the treatment of Paget's disease.Ann Rheum Dis. 1985 Jan;44(1):34-8. doi: 10.1136/ard.44.1.34. Ann Rheum Dis. 1985. PMID: 3918513 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
