doi: 10.1016/s0140-6736(79)91319-9.
Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.)
- PMID: 86043
- DOI: 10.1016/s0140-6736(79)91319-9
Item in Clipboard
Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.)
Lancet.
.
Abstract
14 patients with osteolytic bone disease due to breast cancer or myeloma, 7 of whom had hypercalcaemia, received oral treatment with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.). Serum-calcium dropped to low normal values in all 14 patients, accompanied by a decrease in urine calcium and hydroxyproline excretion-rate. The results show that A.P.D. may inhibit tumour-induced osteolysis.
Similar articles
-
[Treatment of hypercalcemia in osteolytic metastases with oral amino-hydroxypropylidene-diphosphonate].Presse Med. 1984 Feb 25;13(8):483-6. Presse Med. 1984. PMID: 6230630 French.
-
[Role of diphosphonates in the therapy of osteolysis and malignant hypercalcemia].Rev Rhum Mal Osteoartic. 1984 Dec 15;51(11):663-6. Rev Rhum Mal Osteoartic. 1984. PMID: 6523018 French. No abstract available.
-
3(Amino-1,1-hydroxypropylidene) bisphosphonate (APD) for hypercalcaemia of breast cancer.Br J Cancer. 1987 Oct;56(4):465-9. doi: 10.1038/bjc.1987.225. Br J Cancer. 1987. PMID: 3689664 Free PMC article.
-
Osteolytic bone metastases in breast carcinoma pathogenesis, morbidity and bisphosphonate treatment.Eur J Cancer Clin Oncol. 1986 Apr;22(4):493-500. doi: 10.1016/0277-5379(86)90117-3. Eur J Cancer Clin Oncol. 1986. PMID: 2942409 Review.
-
Use of bisphosphonates in cancer patients.Cancer Treat Rev. 1996 Jul;22(4):265-87. doi: 10.1016/s0305-7372(96)90020-1. Cancer Treat Rev. 1996. PMID: 9025784 Review. No abstract available.
Cited by
-
Renal handling of calcium and sodium in metastatic and non-metastatic malignancy.Br Med J (Clin Res Ed). 1986 Mar 1;292(6520):583-6. doi: 10.1136/bmj.292.6520.583. Br Med J (Clin Res Ed). 1986. PMID: 3081177 Free PMC article.
-
The effect of diphosphonates on periosteal and bone cells in culture.Experientia. 1981;37(8):817-9. doi: 10.1007/BF01985657. Experientia. 1981. PMID: 6456927
-
Effects of new bisphosphonic acids on tumor-induced bone destruction in the rat.J Cancer Res Clin Oncol. 1986;111(1):35-41. doi: 10.1007/BF00402773. J Cancer Res Clin Oncol. 1986. PMID: 3949849 Free PMC article.
-
Effect of diphosphonates on ATP and Pi content, Pi uptake and energy charge of cultured calvaria cells.Experientia. 1982 Jun 15;38(6):644-6. doi: 10.1007/BF01964068. Experientia. 1982. PMID: 6213423 No abstract available.
-
Drug treatment of primary hyperparathyroidism: use of clodronate disodium.Br Med J (Clin Res Ed). 1983 Feb 19;286(6365):587-90. doi: 10.1136/bmj.286.6365.587. Br Med J (Clin Res Ed). 1983. PMID: 6218861 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
