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Comparative Study
. 1979 Apr 14;1(8120):805-7.
doi: 10.1016/s0140-6736(79)91320-5.

Urinary beta 2 microglobulin in upper and lower urinary-tract infections

G Schardijn, L W Statius van Eps, A J Swaak, J C Kager, J P Persijn
Comparative Study

Urinary beta 2 microglobulin in upper and lower urinary-tract infections

G Schardijn et al. Lancet. .

Abstract

Beta 2-- microglobulin excretion in 24 h urine collections and beta2- microglobulin clearance were significantly increased in patients with upper-urinary-tract infections, but beta 2- microglobulin clearance and excretion were normal in patients with cystitis. Beta 2-microglobulin estimation may be used to distinguish between upper and lower urinary-tract infections, except when pre-existing tubular damage is present. Voided urine must have a pH above 6 . 0, since beta 2- microglobulin is rapidly degraded in the bladder at low pH.

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