Potential for bias in epidemiologic studies that rely on glass-based retrospective assessment of radon

Abstract

Retrospective assessment of exposure to radon remains the greatest challenge in epidemiologic efforts to assess lung cancer risk associated with residential exposure. An innovative technique based on measurement of alpha-emitting, long-lived daughters embedded by recoil into household glass may one day provide improved radon dosimetry. Particulate air pollution is known, however, to retard the plate-out of radon daughters. This would be expected to result in a differential effect on dosimetry, where the calibration curve relating the actual historical radon exposure to the remaining alpha-activity in the glass would be different in historically smoky and nonsmoky environments. The resulting "measurement confounding" can distort inferences about the effect of radon and can also produce spurious evidence for synergism between radon exposure and cigarette smoking.