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Review
. 1995;7(3):517-20.
doi: 10.1071/rd9950517.

Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS

T Zakar  1 , D M Olson
Affiliations
Review

Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS

T Zakar et al. Reprod Fertil Dev. 1995.

Abstract

The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation.

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