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Case Reports
. 1977 Apr;34(4):408-9.

Apparent theophylline half-life fluctuations during treatment of acute left ventricular failure

J W Jenne, T W Chick, B A Miller, R D Strickland
  • PMID: 860722
Case Reports

Apparent theophylline half-life fluctuations during treatment of acute left ventricular failure

J W Jenne et al. Am J Hosp Pharm. 1977 Apr.

Abstract

The administration of theophylline in a 63-year-old man with arteriosclerotic heart disease and chronic bronchitis is discussed to illustrate the pharmacokinetics of theophylline in an abnormal host state. The case demonstrates that clearly acute congestive heart failure and its treatment may dramatically affect the kinetics of theophylline elimination. Possible explanations for this phenomenon are presented, and the therapeutic implications are discussed.

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