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. 1994;5(3-4):163-70.

Syntheses and effect of bursin and it analogs on the reduced B lymphocytes of uremic patients

T Abiko  1 , H Sekino
Affiliations
  • PMID: 8608325

Syntheses and effect of bursin and it analogs on the reduced B lymphocytes of uremic patients

T Abiko et al. Biotechnol Ther. 1994.

Abstract

A selective B-lymphocyte-differentiating tripeptide, bursin, H-Lys-His-Gly-NH2, and its 10 analogs were synthesized by a solid-phase method and were tested for their effect on reduced B lymphocytes of uremic patients. Incubation of peripheral lymphocytes isolated from uremic patients with the synthetic bursin showed an enhancing effect on the reduced B lymphocytes. Of the s synthetic analogs, [Sar3]bursin exhibited the most potent effect.

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