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Review
. 1996 Feb;22(2):156-60.
doi: 10.1111/j.1524-4725.1996.tb00499.x.

The use of antioxidants in healing

A Martin  1
Affiliations
Review

The use of antioxidants in healing

A Martin. Dermatol Surg. 1996 Feb.

Abstract

Background: Antioxidants enhance the healing of infected and noninfected wounds by reducing the damage caused by oxygen radicals.

Objective: Studies were conducted to determine if the CTR components (vitamin E, sodium pyruvate, and specific fatty acids) could synergistically enhance healing.

Methods: In vitro and in vivo studies were used to assess the effect of various combinations of CRT components.

Results: CTR reduced oxidative damage to keratinocytes and monocytes exposed to ultraviolet light and toxic chemicals and provided protection to human subjects exposed to ultraviolet irradiation. CTR dramatically facilitated healing of infected and noninfected wounds. In herpes-infected guinea pigs, CTR reduced vaginal viral lesion development, severity, and duration, thus facilitated healing of the lesions. CTR also reversed doxorubicin cytotoxicity in monocytes and reversed doxorubicin-impaired wound healing in rats.

Conclusion: The CTR components worked synergistically to enhancing healing of injuries.

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