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Clinical Trial
. 1996 Feb;87(2):206-11.
doi: 10.1111/j.1349-7006.1996.tb03160.x.

A prospective randomized trial of the preventive effect of pre-operative transcatheter arterial embolization against recurrence of hepatocellular carcinoma

S Yamasaki  1 , H Hasegawa, H Kinoshita, M Furukawa, S Imaoka, K Takasaki, Y Kakumoto, H Saitsu, R Yamada, Y Oosaki, S Arii, E Okamoto, M Monden, M Ryu, S Kusano, T Kanematsu, K Ikeda, M Yamamoto, T Saoshiro, T Tsuzuki
Affiliations
Clinical Trial

A prospective randomized trial of the preventive effect of pre-operative transcatheter arterial embolization against recurrence of hepatocellular carcinoma

S Yamasaki et al. Jpn J Cancer Res. 1996 Feb.

Abstract

To clarify whether pre-operative transcatheter arterial embolization (TAE) improves survival after hepatectomy, a prospective randomized comparative study was done. Of a total of 115 registered patients having solitary hepatocellular carcinoma (HCC) 2 to 5 cm in diameter, 18 (15.7%) were excluded after randomization. As a result, 97 patients were chosen as subjects and divided into two groups: hepatectomy with (group A: n=50) and without (group B: n=47) pre-operative TAE. The period of observation of the patients who survived the surgery was between 4.0 and 6.6 years. The randomization appeared to have provided well-balanced groups of patients and the clinico-pathological characteristics of the two groups were quite similar. The necrotic part of the cancerous lesions, as confirmed by operative specimens, amounted to 74.8+/-33.4% (mean +/-SD) in group A and 6.8+/-7.2% in group B (P<0.01). However, the cancer-free survival rates after hepatectomy in both groups showed little difference (39.1+/-7.0 (%+/-SE) and 31.1+/-0.1, respectively). We speculate that TAE is not effective against such HCC accessory lesions as minute intrahepatic metastasis and tumor thrombus and that pre-operative TAE does not improve post-operative survival.

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References

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