doi: 10.1038/381127a0.
Crystal structure of a yeast TFIIA/TBP/DNA complex
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- PMID: 8610010
- DOI: 10.1038/381127a0
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Crystal structure of a yeast TFIIA/TBP/DNA complex
Nature.
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Abstract
The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.
Comment in
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Picking up the TAB.Nature. 1996 May 9;381(6578):112-3. doi: 10.1038/381112a0. Nature. 1996. PMID: 8610004 No abstract available.
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