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. 1995:399:21-31.
doi: 10.1177/0284185195036s39903.

Synthesis and characterization of iodixanol

H Priebe  1 , H Dugstad, M Gacek, E Hagen, O M Homestad, A Larsen, C E Sjogren, T Thomassen
Affiliations

Synthesis and characterization of iodixanol

H Priebe et al. Acta Radiol Suppl. 1995.

Abstract

Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.

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