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Clinical Trial
. 1995 Dec;173(6):1874-8.
doi: 10.1016/0002-9378(95)90444-1.

Low-dose versus high-dose oxytocin augmentation of labor--a randomized trial

E M Xenakis  1 , O Langer, J M Piper, D Conway, M D Berkus
Affiliations
Clinical Trial

Low-dose versus high-dose oxytocin augmentation of labor--a randomized trial

E M Xenakis et al. Am J Obstet Gynecol. 1995 Dec.

Abstract

Objective: Our purpose was to compare the efficacy and safety of low-dose versus high-dose oxytocin regimens in the augmentation of labor.

Study design: Three hundred ten term pregnancies requiring augmentation of labor underwent randomization to receive either a low-dose or high-dose oxytocin augmentation regimen. Maternal demographics, labor-delivery data, and neonatal outcome were compared.

Results: The high-dose oxytocin group had a significantly lower cesarean section rate, regardless of parity (10.4% vs 25.7%, p < 0.001), with no differences in maternal complications and neonatal outcomes. The time needed to correct the labor abnormality was also significantly decreased (1.24 +/- 1.4 hours vs 3.12 +/- 1.6 hours, p < 0.001) in the high-dose group.

Conclusions: The use of high-dose oxytocin regimen benefits both nulliparous and multiparous women requiring labor augmentation by significantly lowering both the time necessary to correct the labor abnormality and the need for cesarean section.

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Comment in

  • High-dose oxytocin.
    Dombrowski MP, Bottoms SF. Dombrowski MP, et al. Am J Obstet Gynecol. 1996 Jul;175(1):240. doi: 10.1016/s0002-9378(96)70300-9. Am J Obstet Gynecol. 1996. PMID: 8694069 No abstract available.
  • A "randomized" controlled trial without randomization.
    Grimes DA, Schulz KF. Grimes DA, et al. Am J Obstet Gynecol. 1996 Jul;175(1):240-1. doi: 10.1016/s0002-9378(96)70302-2. Am J Obstet Gynecol. 1996. PMID: 8694070 No abstract available.

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