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. 1977 Apr;4(2):213-21.
doi: 10.1111/j.1365-2125.1977.tb00697.x.

Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response

J K Aronson, D G Grahame-Smith, K F Hallis, A Hibble, F Wigley

Monitoring digoxin therapy: I. Plasma concentrations and an in vitro assay of tissue response

J K Aronson et al. Br J Clin Pharmacol. 1977 Apr.

Abstract

1 An in vitro technique is described for measuring the uptake of 86Rb by human erythrocytes. 2 Fifteen patients were treated with digoxin for atrial fibrillation and other fast arrhythmias. 3 86Rb uptake by the patients' own red cells fell from pre-treatment values during digitalization. 4 The therapeutic response of patients with atrial fibrillation correlated better with the changes in 86Rb uptake than with plasma digoxin concentrations.

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