Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Apr;4(2):223-7.
doi: 10.1111/j.1365-2125.1977.tb00698.x.

Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution

J K Aronson, D G Grahame-Smith

Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution

J K Aronson et al. Br J Clin Pharmacol. 1977 Apr.

Abstract

1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed.

PubMed Disclaimer

References

    1. Physiol Rev. 1965 Jul;45:596-617 - PubMed
    1. Br J Clin Pharmacol. 1977 Apr;4(2):213-21 - PubMed
    1. Clin Pharmacol Ther. 1975 Jul;18(1):9-21 - PubMed
    1. Nature. 1965 Sep 18;207(5003):1301-2 - PubMed
    1. Res Commun Chem Pathol Pharmacol. 1976 Jan;13(1):9-18 - PubMed

LinkOut - more resources