Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1996 May;3(5):470-9.
doi: 10.1038/nsb0596-470.

The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution

A Cleasby  1 , A Wonacott, T Skarzynski, R E Hubbard, G J Davies, A E Proudfoot, A R Bernard, M A Payton, T N Wells
Affiliations
Comparative Study

The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution

A Cleasby et al. Nat Struct Biol. 1996 May.

Abstract

Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.

PubMed Disclaimer

Publication types

LinkOut - more resources