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. 1996 Feb;46(2):465-9.
doi: 10.1212/wnl.46.2.465.

Valproic acid hepatic fatalities. III. U.S. experience since 1986

A E Bryant 3rd  1 , F E Dreifuss
Affiliations

Valproic acid hepatic fatalities. III. U.S. experience since 1986

A E Bryant 3rd et al. Neurology. 1996 Feb.

Abstract

We report the results of a third retrospective study of the U.S. experience with fatal hepatotoxicity associated with valproic acid (VPA). In the United States, over one million patients received new prescriptions for VPA during the years 1987 to 1993, and 29 patients developed fatal hepatotoxicity. Decreased alertness, jaundice, vomiting, hemorrhage, increased seizures, anorexia, and edema were the most common presenting signs. Risk factors included young age, polytherapy, developmental delay, and coincident metabolic disorders. Patients less than 2 years old receiving VPA as polytherapy were at the greatest risk (1:600) of developing this complication.

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  • Valproate toxicity.
    Parra J, Iriarte J, Pierre-Louis SJ. Parra J, et al. Neurology. 1996 Dec;47(6):1608. doi: 10.1212/wnl.47.6.1608. Neurology. 1996. PMID: 8960763 No abstract available.

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