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. 1996 Apr 26;272(5261):533-5.
doi: 10.1126/science.272.5261.533.

Role of type I myosins in receptor-mediated endocytosis in yeast

M I Geli  1 , H Riezman
Affiliations

Role of type I myosins in receptor-mediated endocytosis in yeast

M I Geli et al. Science. .

Abstract

Type I myosins are thought to drive actin-dependent membrane motility, but the direct demonstration in vivo of their involvement in specific cellular processes has been difficult. Deletion of the genes MYO3 and MYO5, which encode the yeast type I myosins, almost abolished growth. A double-deleted mutant complemented with a MYO5 temperature-sensitive allele (myo5-1) showed a strong defect in the internalization step of receptor-mediated endocytosis, whereas the secretory pathway remained apparently unaffected. Thus, myosin I activity is required for a budding event in endocytosis but not for several other aspects of membrane traffic.

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