Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 May;2(5):534-9.
doi: 10.1038/nm0596-534.

Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart

F J Giordano  1 , P Ping, M D McKirnan, S Nozaki, A N DeMaria, W H Dillmann, O Mathieu-Costello, H K Hammond
Affiliations

Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart

F J Giordano et al. Nat Med. 1996 May.

Abstract

Increased coronary blood vessel development could potentially benefit patients with ischemic heart disease. In a model of stress-induced myocardial ischemia, intracoronary injection of a recombinant adenovirus expressing human fibroblast growth factor-5 (FGF-5) resulted in messenger RNA and protein expression of the transferred gene. Two weeks after gene transfer, regional abnormalities in stress-induced function and blood flow were improved, effects that persisted for 12 weeks. Improved blood flow and function were associated with evidence of angiogenesis. This report documents, for the first time, successful amelioration of abnormalities in myocardial blood flow and function following in vivo gene transfer.

PubMed Disclaimer

Comment in

  • Food for starving hearts.
    Simons M, Ware JA. Simons M, et al. Nat Med. 1996 May;2(5):519-20. doi: 10.1038/nm0596-519. Nat Med. 1996. PMID: 8616705 No abstract available.

Publication types

Substances

LinkOut - more resources