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Clinical Trial
. 1996 Apr;128(4):573-6.
doi: 10.1016/s0022-3476(96)70375-x.

Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies

D G McCarver-May  1 , J Kang, M Aouthmany, R Elton, J L Mowery, T L Slovis, R Kauffman
Affiliations
Clinical Trial

Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies

D G McCarver-May et al. J Pediatr. 1996 Apr.

Abstract

In a crossover study of seven term neonates who had neuroimaging studies, chloral hydrate (75 mg/kg administered orally) was more efficacious (p<0.05) but similar with regard to toxic effects than midazolam (0.2 mg/kg administered intravenously). Thus newer drugs are not necessarily better, and monitoring is essential even after a single oral sedative dose.

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