Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1995 Dec 19;92(26):12151-5.
doi: 10.1073/pnas.92.26.12151.

Phospholipase D signaling is essential for meiosis

K Rose  1 , S A Rudge, M A Frohman, A J Morris, J Engebrecht
Affiliations
Comparative Study

Phospholipase D signaling is essential for meiosis

K Rose et al. Proc Natl Acad Sci U S A. .

Abstract

Phospholipid metabolism plays an important role in cellular regulation by generating second messengers for signal transduction. Many stimuli activate a phospholipase D, which catalyzes the hydrolysis of phosphatidylcholine, producing phosphatidic acid and choline. Here we report that the yeast SP014 gene, which is essential for meiosis [Honigberg, S. M., Conicella, C. & Esposito, R. E. (1992) Genetics 130, 703-716], encodes a phospholipase D. SP014 RNA and protein activity are induced during late meiotic prophase, and the enzyme has properties similar to mammalian phosphatidylinositol 4,5-bisphosphate-regulated phospholipase D. Characterization of an unusual allele of SP014 defines regions of the protein important for enzyme catalysis and regulation. These results implicate phospholipase D signaling in regulating cellular differentiation.

PubMed Disclaimer

References

    1. J Neurochem. 1987 May;48(5):1597-603 - PubMed
    1. Nature. 1986 Sep 11-17;323(6084):171-3 - PubMed
    1. Cell. 1988 Jan 15;52(1):63-71 - PubMed
    1. Cell. 1988 Jul 29;54(3):403-11 - PubMed
    1. Gene. 1988 Oct 30;70(2):303-12 - PubMed

Publication types

MeSH terms