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. 1996 May;145(5):641-3.

Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA)

H C Box  1 , E E Budzinski, J D Dawidzik, J C Wallace, M S Evans, J S Gobey
Affiliations
  • PMID: 8619032

Radiation-induced formation of a crosslink between base moieties of deoxyguanosine and thymidine in deoxygenated solutions of d(CpGpTpA)

H C Box et al. Radiat Res. 1996 May.

Abstract

A new type of tandem base lesion has been observed in d(CpGpTpA) X-irradiated in aqueous solution. The lesion is attributed to the formation of a covalent bond between the C8 carbon atom of guanine and the methyl carbon atom of thymine. This tandem base lesion is formed in the absence of oxygen. It is the main product produced by ionizing radiation under these conditions.

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