Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1995 Sep 30;11(12):1115-27.
doi: 10.1002/yea.320111202.

Ribosomal frameshifting in yeast viruses

J D Dinman  1
Affiliations
Review

Ribosomal frameshifting in yeast viruses

J D Dinman. Yeast. .

Abstract

Proper maintenance of translational reading frame by ribosomes is essential for cell growth and viability. In the last 10 years it has been shown that a number of viruses induce ribosomes to shift reading frame in order to regulate the expression of gene products having enzymatic functions. Studies on ribosomal frameshifting in viruses of yeast have been particularly enlightening. The roles of viral mRNA sequences and secondary structures have been elucidated and a picture of how these interact with host chromosomal gene products is beginning to emerge. The efficiency of ribosomal frameshifting is important for viral particle assembly, and has identified ribosomal frameshifting as a potential target for antiviral agents. The availability of mutants of host chromosomal gene products involved in maintaining the efficiency of ribosomal frameshifting bodes well for the use of yeast in future studies of ribosomal frameshifting.

PubMed Disclaimer

References

    1. Atkins, J. F. , Weills, R. B. , Thompson, S. and Gesteland, R. F. E. (1991). Toward a genetic dissection of the basis of triplet decoding, and its natural subversion: programmed reading frame shifts and hops. Annu. Rev. Genet. 25, 201–228. - PubMed
    1. Balasundaram, D. , Dinman, J. D. , Wickner, R. B. , Tabor, C. W. and Tabor, H. (1994). Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae . Proc. Natl. Acad. Sci. USA 91, 172–176. - PMC - PubMed
    1. Balasundaram, D. , Dinman, J. D. , Tabor, C. W. and Tabor, H. (1994). SPE1 and SPE2: Two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae . J. Bacteriol. 176, 7126–7128. - PMC - PubMed
    1. Belcourt, M. F. and Farabaugh, P. J. (1990). Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site. Cell 62, 339–352. - PMC - PubMed
    1. Blanc, A. , Goyer, C. and Sonenberg, N. (1992). The coat protein of the yeast double‐stranded RNA virus L‐A attaches covalently to the cap structure of eukaryotic mRNA. Mol. Cell. Biol. 12, 3390–3398. - PMC - PubMed

LinkOut - more resources