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. 1977 Mar;27(3):397-400.

Complement in the induction of IgE antibody formation

M B Pepys, W D Brighton, B E Hewitt, D E Bryant, J Pepys

Complement in the induction of IgE antibody formation

M B Pepys et al. Clin Exp Immunol. 1977 Mar.

Abstract

The IgE antibody response of NIH mice to ovalbumin was suppressed by in vivo complement depletion with cobra factor. This observation extends to IgE the finding that complement participates in thymus-dependent antibody formation. Control mice producing IgI anti-ovalbumin antibody after boosting all developed marked peripheral eosinophilia, whereas mice in which the IgE antibody response had been suppressed by cobra factor did not. Administration of cobra factor itself had no effect on peripheral eosinophil levels.

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References

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