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. 1977 Mar;27(3):538-44.

Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody

A Cooke, J H Playfair

Hyper-responsiveness in NZB mice to the experimental induction of anti-red cell autoantibody

A Cooke et al. Clin Exp Immunol. 1977 Mar.

Abstract

Strain differences in ease of induction of autoantibody production were observed when mice were injected with rat RBC. Responsiveness was not linked to the H-2 locus. NZB and (NZB X BALB/c)F1 mice were hyper-responsive both in terms of the induction of autoantibody and in the production of agglutinating antibody to rat RBC. C57BL/c and (C57BL X BALB/c)F1 were poor responders. Injection of the rat RBC in FCA converted a poor responder into a good responder. Adult thymectomy and ALS treatment did not significantly enhance autoantibody production.

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