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. 1996 Apr 16;93(8):3341-5.
doi: 10.1073/pnas.93.8.3341.

Why are some proteins structures so common?

S Govindarajan  1 , R A Goldstein
Affiliations

Why are some proteins structures so common?

S Govindarajan et al. Proc Natl Acad Sci U S A. .

Abstract

Many biological proteins are observed to fold into one of a limited number of structural motifs. By considering the requirements imposed on proteins by their need to fold rapidly, and the ease with which such requirements can be fulfilled as a function of the native structure, we can explain why certain structures are repeatedly observed among proteins with negligible sequence similarity. This work has implications for the understanding of protein sequence structure relationships as well as protein evolution.

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References

    1. Science. 1991 Dec 13;254(5038):1598-603 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4163-7 - PubMed
    1. Biochemistry. 1995 Jan 31;34(4):1133-6 - PubMed
    1. Proteins. 1995 Jun;22(2):81-99 - PubMed
    1. Nature. 1994 May 19;369(6477):248-51 - PubMed

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