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. 1996 May;178(9):2718-20.
doi: 10.1128/jb.178.9.2718-2720.1996.

Synonymous codon selection controls in vivo turnover and amount of mRNA in Escherichia coli bla and ompA genes

A Deana  1 , R Ehrlich, C Reiss
Affiliations

Synonymous codon selection controls in vivo turnover and amount of mRNA in Escherichia coli bla and ompA genes

A Deana et al. J Bacteriol. 1996 May.

Abstract

A number of silent codon changes were made in two Escherichia coli genes. For the ompA gene, the replacement of seven consecutive frequently used codons with synonymous infrequently used codons reduced the ompA mRNA level and its half-life. For the bla gene, the exchange of 24 codons for the most frequently used synonymous codons extended the bla mRNA half-life. A modification of ribosome traffic could account for these observations.

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