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. 1996 Feb 1;183(2):639-44.
doi: 10.1084/jem.183.2.639.

Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

Y Li  1 , K E Hellstrom, S A Newby, L Chen
Affiliations

Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors

Y Li et al. J Exp Med. .

Abstract

Genetic modification of many types of mouse tumors to express the B7-1 or B7-2 molecules, natural ligands for the T cell-costimulatory molecule CD28, increases their immunogenicity. However, even after transfection with the B7-1 and/or B7-2 genes, poorly immunogenic tumors fail to elicit and efficient immune response. We report here that two such tumors, the Ag104A sarcoma and the K1735-M2 melanoma, become immunogenic after transfection of the genes encoding murine B7-1 together with CD48, which is the natural ligand for CD2. Tumor-specific CD8+ cytotoxic T lymphocytes were readily generated and were effective for adoptive immunotherapy of metastasis induced by wild-type Ag104A sarcoma cells. A similar approach may be useful for developing therapy for other poorly immunogenic tumors, including those in humans.

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