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. 1977 May 15;33(5):643-5.
doi: 10.1007/BF01946550.

Spectral changes resulting from the interaction of some N-alkyl nitrosamines and rat liver microsomes

M I Diaz Gomez, J A Castro

Spectral changes resulting from the interaction of some N-alkyl nitrosamines and rat liver microsomes

M I Diaz Gomez et al. Experientia. .

Abstract

Dimethyl (DMN) and diethyl nitrosamine (DEN) do not give characteristic spectral changes upon interaction with rat liver microsomes, while dipropyl (DPN) and dibutyl (DBN) nitrosamine cause type I spectral changes. The spectral binding constant is 100 mM for DPN and 1.17 mM for DBN. The maximal spectral change is 3.2 X 10(6) and 1.0 X 10(6) absorbance units per milligram protein for DPN and DBN respectively.

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