Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1977 May 15;33(5):646-8.
doi: 10.1007/BF01946552.

Thymus gland involution induced by lithium chloride

J Pérez-Cruet, J T Dancey
Comparative Study

Thymus gland involution induced by lithium chloride

J Pérez-Cruet et al. Experientia. .

Abstract

Chronic treatment with lithium chloride produced significant involution of the thymus gland with histological evidence of reduced cellularity due to loss of thymic lymphocytes and a significant reduction in the weight of the gland in normal and adrenalectomized mice. Lithium also increased corticosterone levels in normal mice without changes in adrenal weights. The involution of the thymus gland is most likely due to an effect of lithium on the gland, and it is not mediated by adrenocortical mechanisms or stress.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Pharmacol Exp Ther. 1971 Aug;178(2):325-30 - PubMed
    1. Life Sci. 1966 Aug;5(16):1479-83 - PubMed
    1. Dis Nerv Syst. 1970 Apr;31(4):237-44 - PubMed
    1. Arzneimittelforschung. 1971 Sep;21(9):1363-4 - PubMed
    1. J Clin Endocrinol Metab. 1972 Nov;35(5):678-83 - PubMed

Publication types