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Comparative Study
. 1977 May 15;33(5):646-8.
doi: 10.1007/BF01946552.

Thymus gland involution induced by lithium chloride

J Pérez-Cruet, J T Dancey
Comparative Study

Thymus gland involution induced by lithium chloride

J Pérez-Cruet et al. Experientia. .

Abstract

Chronic treatment with lithium chloride produced significant involution of the thymus gland with histological evidence of reduced cellularity due to loss of thymic lymphocytes and a significant reduction in the weight of the gland in normal and adrenalectomized mice. Lithium also increased corticosterone levels in normal mice without changes in adrenal weights. The involution of the thymus gland is most likely due to an effect of lithium on the gland, and it is not mediated by adrenocortical mechanisms or stress.

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