doi: 10.1006/bbrc.1996.0642.
Suppression of translation frameshift by upstream termination codon
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- PMID: 8630007
- DOI: 10.1006/bbrc.1996.0642
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Suppression of translation frameshift by upstream termination codon
Biochem Biophys Res Commun.
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Abstract
Retroviruses employ translation frameshift for gene expression. Translation frameshift takes place at the slippery heptanucleotide sequence on mRNA. A downstream stem-loop structure (and a pseudoknot formed by the stem-loop) enhances the level of ribosomal frameshifting. Here, we describe that an upstream termination codon suppresses the ribosomal frameshifting, leading to reduction in the expression of downstream genes.
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