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Clinical Trial
. 1996 Apr;39(4):623-8.
doi: 10.1002/art.1780390413.

A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis

M L Barnett  1 , D Combitchi, D E Trentham
Affiliations
Clinical Trial

A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis

M L Barnett et al. Arthritis Rheum. 1996 Apr.

Abstract

Objective: To evaluate the efficacy of oral chicken type II collagen (CCII) in the treatment of juvenile rheumatoid arthritis (JRA).

Methods: Ten patients with active JRA were treated with CCII for 12 weeks. Efficacy parameters, which included swollen and tender joint count and score, grip strength, 50-foot walking time, duration of morning stiffness, and patient and physician global scores of disease severity, were assessed monthly.

Results: All patients completed the full course of therapy. Eight patients had reductions in both swollen and tender joint counts after 3 months of CCII. The mean changes from baseline in swollen and tender joint counts for the 8 responders at the end of the study were -61% and -54%, respectively. Mean values for other efficacy parameters also showed improvement from baseline. There were no adverse events that were considered to be treatment related.

Conclusion: Oral CCII may be a safe and effective therapy for JRA, and its use in this disease warrants further investigation.

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