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. 1996 Mar;178(5):1347-50.
doi: 10.1128/jb.178.5.1347-1350.1996.

Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli

D R Koehler  1 , J Courcelle, P C Hanawalt
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Kinetics of pyrimidine(6-4)pyrimidone photoproduct repair in Escherichia coli

D R Koehler et al. J Bacteriol. 1996 Mar.

Abstract

We compared the removal of pyrimidine(6-4)pyrimidone photoproducts [(6-4) photoproducts] and cyclobutane pyrimidine dimers (CPDs) from the genome of repair-proficient Escherichia coli, using monoclonal antibodies specific for each type of lesion. We found that (6-4) photoproducts were removed at a higher rate than CPDs in the first 30 min following a moderate UV dose (40 J/m2). The difference in rates was less than that typically reported for cultured mammalian cells, in which the removal of (6-4) photoproducts is far more rapid than that of CPDs.

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