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Case Reports
. 1996 May;34(5 Pt 1):781-4.
doi: 10.1016/s0190-9622(96)90013-4.

Colchicine for epidermolysis bullosa acquisita

B B Cunningham  1 , T T Kirchmann, D Woodley
Affiliations
Case Reports

Colchicine for epidermolysis bullosa acquisita

B B Cunningham et al. J Am Acad Dermatol. 1996 May.

Abstract

Background: Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease that is difficult to treat. Recently one patient with severe EBA was described who responded dramatically to colchicine.

Objective: Our purpose was to determine the efficacy of colchicine in the treatment of EBA.

Methods: Four patients with severe EBA refractory to conventional therapy were treated with colchicine 0.6 to 1.5 mg a day for up to 4 years.

Results: In all four patients the lessening of skin fragility and the decrease in spontaneous blister formation were dramatic; few side effects were noted.

Conclusion: Colchicine should be considered in the treatment of EBA.

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