Serum haptoglobin concentrations in a population of feedlot cattle

Abstract

Objective: To determine serum haptoglobin concentrations in a population of feedlot cattle and evaluate their usefulness in predicting subsequent clinical respiratory tract disease.

Design: Prospective longitudinal study.

Animals: 366 beef calves.

Procedure: Serum samples were obtained at feedlot entry and 40 and 65 days on feed (DOF). Calves were observed daily for clinical signs of respiratory tract disease. The lungs of 144 of the calves were evaluated at slaughter for the presence of gross lesions of pneumonia.

Results: 58% of the calves had detectable serum haptoglobin concentration in at least 1 sample. The proportion of calves with detectable haptoglobin were similar at each sample collection time. A higher proportion of the calves had values > 10 mg/dl at 40 DOF. The proportion of calves observed with clinical disease during the 10-day period after the 40 DOF sample increased (P < 0.10) as serum haptoglobin concentration increased. At 65 DOF, calves with serum haptoglobin value > 10 mg/dl had a higher (P < 0.05) rate of subsequent clinical respiratory tract disease than did calves with lower values. The proportion of calves with gross pulmonary lesions slaughter increased (P < 0.05) from 39% among calves without detectable serum haptoglobin concentration in any of the 3 samples to 63% among calves with at least 1 observed value > 10 mg/dl.

Conclusions: We observed associations between serum haptoglobin concentration and subsequent clinical respiratory tract disease and pulmonary lesions at slaughter. However, serum haptoglobin concentration alone is not adequate for prediction of clinical disease.

Clinical relevance: The usefulness for cross-sectional sampling of serum haptoglobin concentration as a diagnostic tool for clinical respiratory tract disease in feedlot cattle appears to be limited.