Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1996 Apr;223(4):357-62.
doi: 10.1097/00000658-199604000-00003.

Protein-sparing therapy after major abdominal surgery: lack of clinical effects. Protein-Sparing Therapy Study Group

G B Doglietto  1 , L Gallitelli, F Pacelli, R Bellantone, M Malerba, A Sgadari, F Crucitti
Affiliations
Clinical Trial

Protein-sparing therapy after major abdominal surgery: lack of clinical effects. Protein-Sparing Therapy Study Group

G B Doglietto et al. Ann Surg. 1996 Apr.

Abstract

Objective: A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative protein-sparing therapy.

Summary background data: The metabolic effect of postoperative protein-sparing therapy has been shown by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials.

Methods: Six hundred seventy-eight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (protein-sparing therapy group) or conventional therapy (control group). The patients were monitored for postoperative complications and mortality.

Results: The rate of major postoperative complications was similar in both groups (protein-sparing therapy group, 19.5%; control group, 20.9%; p=0.66) as were the overall postoperative mortality rates (4.7% and 3.5%, respectively; p=0.43).

Conclusions: The present study indicates that routine protein-sparing therapy for patients normonourished or mildly malnourished undergoing major abdominal surgery is not clinically justified.

PubMed Disclaimer

References

    1. N Engl J Med. 1976 Jun 24;294(26):1411-6 - PubMed
    1. Metabolism. 1978 Mar;27(3):325-31 - PubMed
    1. JPEN J Parenter Enteral Nutr. 1988 Mar-Apr;12(2):195-7 - PubMed
    1. Am J Clin Nutr. 1988 Feb;47(2 Suppl):366-81 - PubMed
    1. World J Surg. 1986 Feb;10(1):64-71 - PubMed

Substances