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. 1995 Nov;51(2):127-31.
doi: 10.1016/0020-7292(95)02533-i.

Familial predisposition to uterine leiomyomas

E M Vikhlyaeva  1 , Z S Khodzhaeva, N D Fantschenko
Affiliations

Familial predisposition to uterine leiomyomas

E M Vikhlyaeva et al. Int J Gynaecol Obstet. 1995 Nov.

Abstract

Objective: To study the clinical risk for gynecological disorders in first-degree relatives in families with uterine leiomyoma.

Method: Ninety-seven families (215 female patients) were enrolled in this study; 97 patients and 118 of their near family relatives were examined.

Results: Leiomyoma was discovered in 24.7% of cases, 2.2 times more frequently (P < 0.001) among the first-degree female relatives in families with two or more verified leiomyoma cases. The rate of PCO disease was about 15% for both groups.

Conclusion: These results confirm the concept of distinct predisposition to uterine leiomyoma and the PCO disease in first-degree relatives in families with leiomyoma accumulation.

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