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. 1996 Mar 21;380(6571):221-6.
doi: 10.1038/380221a0.

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

L Jia  1 , C Bonaventura, J Bonaventura, J S Stamler
Affiliations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

L Jia et al. Nature. .

Abstract

A dynamic cycle exists in which haemoglobin is S-nitrosylated in the lung when red blood cells are oxygenated, and the NO group is released during arterial-venous transit. The vasoactivity of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols. These findings highlight newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure and which may facilitate efficient delivery of oxygen to tissues. The role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications.

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Comment in

  • Infrared astronomy. The real water-bearer.
    Kwok S. Kwok S. Nature. 1996 Mar 21;380(6571):205. doi: 10.1038/380205a0. Nature. 1996. PMID: 8637565 No abstract available.
  • Dynamics of haemoglobin.
    Kagan VE, Day BW, Elsayed NM, Gorbunov NV. Kagan VE, et al. Nature. 1996 Sep 5;383(6595):30-1. doi: 10.1038/383030b0. Nature. 1996. PMID: 8779713 No abstract available.

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