Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Mar 19;93(6):2488-92.
doi: 10.1073/pnas.93.6.2488.

The response regulator SprE controls the stability of RpoS

L A Pratt  1 , T J Silhavy
Affiliations

The response regulator SprE controls the stability of RpoS

L A Pratt et al. Proc Natl Acad Sci U S A. .

Abstract

In Escherichia coli, the sigma factor, RpoS, is a central regulator in stationary-phase cells. We have identified a gene, sprE (stationary-phase regulator), as essential for the negative regulation of rpoS expression. SprE negatively regulates the rpoS gene product at the level of protein stability, perhaps in response to nutrient availability. The ability of SprE to destabilize RpoS is dependent on the ClpX/ClpP protease. Based on homology, SprE is a member of the response regulator family of proteins. SprE is the first response regulator identified that is implicated in the control of protein stability. Moreover, SprE is the first reported protein that appears to regulate rpoS in response to a specific environmental parameter.

PubMed Disclaimer

References

    1. J Bacteriol. 1979 Dec;140(3):843-7 - PubMed
    1. J Bacteriol. 1996 Jan;178(2):470-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 May;86(9):3271-5 - PubMed
    1. Nucleic Acids Res. 1989 Dec 11;17(23):9979-91 - PubMed
    1. J Bacteriol. 1990 Dec;172(12):6713-20 - PubMed

Publication types

MeSH terms

LinkOut - more resources